Episode 65

Episode 65
Lock On
Romaji	Rokku on
Japanese	LOCK (ロック) ON (オン)
JP Air Date	February 27, 2025
U.S. Air Date	February 27, 2025
Adapted From	Chapter 158 Chapter 159 Chapter 160 (p. 1)
Arc	New America City Arc
Opening Song	CASANOVA POSSE by ALI
Ending Song	Rolling Stone by BREIMEN
Episode Guide
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Lock On (LOCK (ロック) ON (オン) , Rokku on) is the sixty-fifth episode of the anime Dr. Stone and the eighth episode of the fourth season.

Summary

NASA scientist Dr. Xeno attempts to pick off the leader of the Kingdom of Science.

Plot Details

The flashback of the American Colony after the petrification continues, revealing that Stanley’s unit obeyed his order to stay awake during the petrification event. Some soldiers notice the statues of Carlos and Max, and assume civilians won’t wake up, only to be surprised when they do. Carlos spits out a preserved platinum ring intended for Luna, which Xeno picks up and realizes can be used to produce a limitless supply of nitric acid—allowing him to rule the Stone World. Meanwhile, the American Colony begins building their fortress, while Senku and Taiju work on creating the Revival Fluid.

Back to the present, Xeno clarifies to Stanley that Senku is the enemy scientist and not Taiju. To identify Senku, Xeno retrieves a recording of Perseus’ transmissions and estimates Senku’s height (5’8”) and age (19). Using Luna as a reference, Stanley narrows his targets down to three. Meanwhile, Ryusui warns the crew about a sniper, causing them to scatter. Luna instinctively looks at Stanley, unintentionally giving away his position. Stanley uses this to his advantage, predicting Senku’s movements based on geometric principles. Before shooting, Stanley confirms with Xeno that he truly wants Senku dead, which Xeno affirms due to their opposing ambitions. As Stanley fires, Senku uses dilatant fluid—tested for bulletproofing—to reduce the bullet’s impact. The episode ends with Senku getting shot.

Characters

• Senku Ishigami
• Yuzuriha Ogawa
• Ryusui Nanami
• Stanley Snyder
• Xeno Houston Wingfield
• Max Adams
• Carlos Barrios
• Maya Biggs
• Brody Dudley
• Minami Hokutozai
• Taiju Oki
• Nikki Hanada
• Luna Wright
• Ginro
• Francois

Locations

• American Colony (San Francisco, USA)

Vehicles

• Perseus

Inventions and Discoveries

• Dilatant Body Armor

Anime to Manga Differences

• A lot of new original content is added to the first half of the episode.
  • Xeno's awakening and finding nitric acid as the source of his awakening are included.
  • When Stan awakens, a conversation is shown between the two, including an adaptation of the Chapter 158 cover page.
  • The Americans and shown finding the location for the American Colony.

Trivia

• The episode's title is based on the events of Chapter 159.